Consider the source (the video will start at the beginning part of the conversation, for proper context): Molyneux is an atheist who is 150% invested in the Western philosophical legacy, stretching all the was back to the big three—Socrates, Plato, and Aristotle. Admitting that reason and evidence isn’t the panacea it’s purported to be is telling. He mentioned it in previous videos, but not quite so succinctly (or profanely).
And, as I have mentioned before, the blob of people known as “society,” cannot be run on “reason and evidence,” because the effectiveness of material epistemology goes straight to zero when broadened above a small group of agents. It’s best at the individual level; when it becomes a overarching strategy, it just ends up being tradition with heavy reliance on reliable authority, i.e., nearly every scientific fact is based on the trust of another’s observations and conclusions, unless we have replicated, via the same process and with the same results. Nearly everyone reading this will not have done this for a majority of scientific facts, including myself. Most implementations of “reason and evidence” as the gold standard for a society to live within usually involve the threat of violence. It really can’t be codified another way.
And even then, individuals only engage in reason and evidence effectively when it’s in small fits and starts, on equally small-scale, easily-perceivable objects: organizing the family calendar in the coming weeks, or following a cake recipe. It can also be effective in slightly larger groups, like a team of engineers working on a propulsion system.
The ethos of “I’m a scientist. I live by logic and reason,” is an bald lie, or at least a very hairy obfuscation of terms. The scientist, like any human, lives nearly entirely on instinct, senses, rote habit, and the force of tradition. The only time he lives by his professed credo is about a quarter of the time he is engaged in his profession.